PANTOTİN 100 mg/ml syrup
PANTOTIN
International non-patented name: Hopantenic acid
Composition
Active substance: 1 ml of syrup contains 100 mg hopantenic acid (hopantenate calcium).
Excipients : fructose, potassium sorbate (E 202), riboflavin, purified water.
Description
It is a thick, clear liquid, light yellow to yellow in color, with a characteristic odor and a sweet taste. A small amount of sediment is possible during storage.
Pharmacotherapeutic group
Psychoanaleptic agent; psychostimulant, agent for the treatment of attention deficit hyperactivity disorder and nootropic agent; other psychostimulants and nootropics.
ATC : N06BX.
Pharmacological properties
Pharmacodynamics
Hopanthenic acid has nootropic (neurotrophic, neurometabolic, neuroprotective), anticonvulsant and sedative properties. It increases the resistance of the brain to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, weakens mobility, increases mental and physical work capacity. Pathologically increased bladder reflex inhibits detrusor tone.
Pharmacokinetics
After oral administration, the drug is rapidly absorbed from the gastrointestinal tract. Tmax is about 1 hour. Hopanthenic acid crosses the HEB. The highest concentration of the drug is observed in the kidneys, liver, skin and walls of the stomach. The drug is not metabolized and is excreted unchanged within 48 hours. 67.5% of the dose is excreted by the kidneys and 28.5% by the gastrointestinal tract.
Instructions for us
- Improvement of concentration, improvement of mental and physical work ability, brain functions and memory;
- to prevent brain disorders in newborns;
- in the complex therapy of epilepsy and schizophrenia, in addition to the treatment of cerebral palsy;
- improvement of symptoms of cerebral atherosclerosis, cerebrovascular diseases;
– as well as:
- extrapyramidal and motor disorders (Myoclonus, Huntington’s disease, hepatolenticular degeneration, Parkinson’s disease);
- intracranial trauma and neuroinfections (organic brain damage);
- neurotic disorders (stuttering, tics, etc.);
- behavioral disorders (hyperactivity and attention deficit);
- neurogenic bladder weakness (polyuria, pollakiuria, imperative urge, imperative incontinence).
Contraindications
Hypersensitivity to the drug, acute renal failure, pregnancy (1st trimester), lactation period, children under 6 months.
Special instructions and precautions
The combined use of nootropic drugs and other CNS stimulants is not recommended. The drug contains fructose. In case of high sensitivity to fructose in case of rare hereditary diseases, it is not advisable to take the drug.
Patients suffering from diabetes should take into account that 1 ml of syrup contains 0.56 g of fructose.
Interaction with other medicines.
The drug prolongs the duration of action of barbiturates, enhances the effect of anticonvulsants and local anesthetics (eg, procaine), prevents side effects of phenobarbital, carbamazepine, antipsychotic drugs (neuroleptics).
When used together with psychostimulants, the mutual stimulating effect is strengthened. The combined use of glycine and etidronic acid increases the effect of the drug.
Use during pregnancy and lactation
It is contraindicated in the first trimester of pregnancy and during lactation. It is not recommended during the II and III periods of pregnancy.
Effects on the ability to drive a vehicle and other potentially dangerous mechanisms
At the beginning of the treatment, when driving a bicycle, motorcycle or truck, as well as other potentially dangerous mechanisms, it is taken with caution based on its side effects (drowsiness, noise in the head).
Method of use and dosage
It is taken internally, 15-30 minutes after food.
The required amount of syrup is measured using an oral syringe or measuring cap. To correctly measure the volume of the syrup, the piston of the oral syringe should be pulled to the end of the cylinder, and then the syringe should be inserted into the syrup, and the piston should be raised to the required amount.
The oral syringe and measuring cap should be washed with warm boiled water before and after use.
For children and adolescents (from 6 months to 8 years):
– in mental retardation: 5 ml 4-6 times a day for 3 months;
– in retardation of speech development: 5 ml 3-4 times a day for 2-3 months;
– in neuroleptic syndrome (for the purpose of correcting side effects of neuroleptic drugs): 2.5-5 ml 3-4 times a day for 1-3 months;
– in epilepsy: 2.5 ml 3-4 times a day for a long time (within 6 months);
– in tics: 2.5-5 ml 3-6 times a day for 1-4 months;
– during urination disorders: 2.5-5 ml 1-2 times a day for 1-3 months, daily dose rate of hopanthenic acid is 25-50 mg/kg;
– during complications of neuroinfections and head injuries: 2.5 ml 3-4 times a day;
– in other diseases of the nervous system:
– From 6 months to 1 year: 5-10 ml per day;
– From 1 to 3 years: 5-12.5 ml per day;
– From 3 to 7 years old: 7.5-15 ml per day;
– Over 7 years old: 10-20 ml per day.
Adults
– in neuroleptic syndrome (for the purpose of correcting side effects of neuroleptic drugs): 5-10 ml 3 times a day for 1-3 months;
– in epilepsy: 5-10 ml 3 times a day for a long time (up to 6 months);
– in tics: 5-10 ml 3 times a day for 1-5 months;
– during urination disorders: 5-10 ml 2-3 times a day for 1-3 months;
– during complications of neuroinfections and head injuries: 2.5 ml 3-4 times a day;
– in schizophrenia (complex with psychotropic drugs): 2.5 ml 2-3 times a day for 1-3 months.
The duration of treatment is 1-4 months, sometimes 6 months. It is possible to repeat the treatment after 3-6 months.
Side effects
In case of hypersensitivity to the component of the drug, cases of allergy may be noted (rhinitis, conjunctivitis, skin rashes).
In rare cases, short-term symptoms may be noted: sleep disturbance or drowsiness, noise in the head, dizziness, headache, hypervigilance, depression, inhibition.
In the case of the above-mentioned cases, it is necessary to stop taking the drug and consult a doctor or pharmacist.
Overdose
Exceeding the dose is not recommended. In order to prevent insomnia, the drug should not be taken later than 5 p.m.
Packing form
100 ml of syrup in a polymer bottle. 1 vial is packed in a cardboard box with an oral syringe or measuring cap and an instruction.
Storage condition
It should be stored at a temperature not higher than 25°C, in the original packaging, in a dark place and out of the reach of children. Do not freeze.
Shelf life
3 years.
By prescription
Manufacturer
JVC “Vitapharm-Com” Ltd., Moldova.
9/5 Lenin street, Comrat, 9/5 MD-3812, ATU Gagauzia , Moldova.